Krejcí I, Dlabac A
Act Nerv Super (Praha). 1984 Jun;26(2):103-11.
Rats maintained on 23-hr water deprivation were first trained to bar-press for continuous water reinforcement and then to discriminate between regularly alternating periods (24 sec) during which time a light signal was either on and each response was reinforced or the light was off and bar-presses were not rewarded. The following drugs were injected s. c. prior to the sessions of discriminative learning: piracetam, 1-(4-Methyl-piperazinocarbonylmethyl)-2-pyrrolidone/hydrogen maleate (VUFB 13763), N alpha-glycyl-glycyl[8-lysine]des-9-glycinamide-vasopressin (DG-Trigly-LVP) and an analog of MIF, EUC-Leu-beta-Ala-NH2 (EUC, 2-oxoimidazolidine-1-carboxylic acid). None of the drugs influenced the total number of bar-pressing (sum of reinforced and non reinforced responses). Piracetam (100 mg.kg-1), VUFB 13763 (40 mg.kg-1) and EUC-Leu-beta-Ala-NH2 (1 mg.kg-1) improved the performance of rats on the discrimination learning task, DG-Trigly-LVP slowed the rate of acquisition.
将大鼠进行23小时禁水处理后，首先训练它们按压杠杆以获取持续的水强化奖励，然后训练它们区分定期交替的时间段（24秒），在此期间，光信号开启时每次按压杠杆都会得到强化，而光信号关闭时按压杠杆则不会得到奖励。在辨别学习实验前，通过皮下注射以下药物：吡拉西坦、1-(4-甲基-哌嗪甲酰甲基)-2-吡咯烷酮/马来酸氢盐（VUFB 13763）、Nα-甘氨酰-甘氨酰[8-赖氨酸]去-9-甘氨酰胺加压素（DG-三甘氨酰-LVP）和巨噬细胞移动抑制因子类似物EUC-亮氨酸-β-丙氨酸-NH2（EUC，2-氧代咪唑烷-1-羧酸）。这些药物均未影响按压杠杆的总数（强化和未强化反应的总和）。吡拉西坦（100毫克/千克）、VUFB 13763（40毫克/千克）和EUC-亮氨酸-β-丙氨酸-NH2（1毫克/千克）改善了大鼠在辨别学习任务中的表现，DG-三甘氨酰-LVP则减缓了习得速度。
