Carroll B A, Young S W, Rasor J S, Briller R B, Cassel D M
Radiology. 1982 Jun;143(3):747-50. doi: 10.1148/radiology.143.3.7079504.
Pilot studies have shown that gelatin encapsulated microbubbles (GEM) are readily demonstrable ultrasonic contrast agents. GEM injected into hepatic and renal blood vessels resulted in increased echogenicity of the parenchyma in normal rabbits. VS carcinoma implanted in the rabbit liver and kidney showed significantly different echogenicity from that of normal parenchyma following GEM injection. Echogenic bubbles were delivered to different regions by varying the size of GEM.
初步研究表明，明胶包裹的微泡（GEM）是易于检测的超声造影剂。将GEM注入正常兔的肝血管和肾血管后，实质回声增强。在兔肝脏和肾脏植入VS癌后，注射GEM后其回声与正常实质有显著差异。通过改变GEM的大小可将回声气泡输送到不同区域。
