Bixler E O, Kales A, Soldatos C R, Vela-Bueno A, Jacoby J A, Scarone S
Res Commun Chem Pathol Pharmacol. 1982 Apr;36(1):141-52.
One hundred subjects without any complaint of sleep disturbance were evaluated in the sleep laboratory for the presence of sleep apnea and sleep apneic activity (SAA). This sample, which had a representative proportion of women and men and a wide age distribution, included only subjects who were physically and mentally healthy and were not using any medication. None of the subjects had the clinical condition of sleep apnea, and only 12 percent of the subjects met the more liberal criterion for SAA. The prevalence of SAA was slightly higher in men than in women. SAA was positively and significantly correlated with increasing age. However, relative severity, as judged by the mean number of events and the duration of events, showed no consistent pattern in relation to age. Further, it was demonstrated that those subjects with SAA were significantly heavier than those without the activity. Neither smoking nor caffeine consumption was related to the presence of SAA. When the amount of each sleep stage was controlled for, SAA occurred significantly more often during REM sleep. A relatively small number of EEG arousals were related to SAA, with only about one-fifth of the events resulting in brief arousals.
在睡眠实验室对100名无睡眠障碍主诉的受试者进行睡眠呼吸暂停和睡眠呼吸暂停活动（SAA）检查。该样本中男女比例具有代表性，年龄分布广泛，仅纳入身心健康且未使用任何药物的受试者。所有受试者均无睡眠呼吸暂停的临床症状，只有12%的受试者符合更为宽松的SAA标准。男性SAA的患病率略高于女性。SAA与年龄增长呈正相关且具有显著性。然而，根据事件平均数和事件持续时间判断的相对严重程度，与年龄并无一致的模式。此外，研究表明，有SAA的受试者明显比没有该活动的受试者体重更重。吸烟和咖啡因摄入均与SAA的存在无关。当控制每个睡眠阶段的时长后，SAA在快速眼动睡眠期间出现的频率显著更高。相对较少的脑电图觉醒与SAA有关，只有约五分之一的事件会导致短暂觉醒。
