被禾本科粒线虫和拉氏棒状杆菌寄生的、以一年生黑麦草（多花黑麦草）为食的绵羊的肝脏损伤

Hepatic damage in sheep fed annual ryegrass, Lolium rigidum, parasitised by Anguina agrostis and Corynebacterium rathayi.

作者信息

Berry P H, Richards R B, Howell J M, Cook R D

出版信息

Res Vet Sci. 1982 Mar;32(2):148-56.

Abstract

Annual ryegrass (Lolium rigidum) parasitised by Anguina agrostis and Corynebacterium rathayi causes neurological signs and brain lesions thought to be associated with a vasoconstrictor effect of the toxic grass. In three separate experiments of six to 112 days duration parasitised ryegrass was fed to 21 adult sheep. The concentrations of many blood constituents were examined, liver biopsies taken, necropsies performed and tissues other than brain examined by light and electron microscopy. The invariable finding was liver damage indicated by increased plasma concentrations of liver specific enzymes and bilirubin. There was diffuse vacuolation of hepatocytes due to gross distension of cisternae of rough endoplasmic reticulum, as well as necrosis of individual hepatocytes, fatty change, biliary hyperplasia and hepatocytic regeneration. The changes were not typical of experimental hepatic ischaemia and may have been due to a cytopathic effect of toxic annual ryegrass.

摘要

被禾本科粒线虫和拉氏棒状杆菌寄生的一年生黑麦草（多花黑麦草）会引发神经症状和脑部病变，这些病变被认为与有毒牧草的血管收缩效应有关。在为期6至112天的三项独立实验中，将被寄生的黑麦草喂给了21只成年绵羊。检测了许多血液成分的浓度，进行了肝脏活检、尸检，并通过光学显微镜和电子显微镜检查了除大脑以外的组织。不变的发现是肝脏损伤，表现为肝脏特异性酶和胆红素的血浆浓度升高。由于粗面内质网池的明显扩张，肝细胞出现弥漫性空泡化，同时还有个别肝细胞坏死、脂肪变性、胆管增生和肝细胞再生。这些变化并非实验性肝缺血的典型表现，可能是由于有毒一年生黑麦草的细胞病变效应所致。