寄生黑麦草（多花黑麦草）提取物对乳鼠的脑损伤

Brain damage by extracts of parasitised annual ryegrass (Lolium rigidum) in nursling rats.

作者信息

Peterson J E, Jago M V

出版信息

Aust J Exp Biol Med Sci. 1977 Jun;55(3):233-44. doi: 10.1038/icb.1977.18.

DOI:10.1038/icb.1977.18

Abstract

Extracts of annual ryegrass (Lolium rigidum) infected with Anguina sp. and Corynebacterium sp., and associated with an outbreak of annual ryegrass toxicity in sheep, were administered to 2-week-old rats by a single intraperitoneal injection. Rats that received a lethal dose of toxin developed neurological signs including incoordination and convulsions from the second day and most died between 2 and 7 days after injection. Histologically, the brains showed widespread lesions of focal necrosis consistent with anoxia. Peripheral circulation rate was greatly reduced after 3 days and gangrene of the tail and hind legs developed in some rats. Evidence of restricted blood flow was also seen in kidneys, lungs and brain. It was concluded that the toxin contains a long-acting vasoconstrictor.

摘要

将感染了Anguina菌属和棒状杆菌属、并与绵羊一年生黑麦草中毒爆发相关的一年生黑麦草（Lolium rigidum）提取物，通过单次腹腔注射给予2周龄大鼠。接受致死剂量毒素的大鼠从第二天开始出现神经症状，包括共济失调和惊厥，大多数在注射后2至7天内死亡。组织学检查显示，大脑出现广泛的局灶性坏死病变，与缺氧一致。3天后外周循环速率大幅降低，一些大鼠出现尾巴和后腿坏疽。在肾脏、肺和大脑中也发现了血流受限的证据。得出的结论是，该毒素含有一种长效血管收缩剂。