Connors B W, Ransom B R, Kunis D M, Gutnick M J
Science. 1982 Jun 18;216(4552):1341-3. doi: 10.1126/science.7079771.
Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+]o) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+]o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K+]o was 17.2 microM in 1- to 3-day-old optic nerves and 9.8 microM in adult nerves. The ceiling [K+]o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release.
使用钾敏感微电极研究不同出生后年龄（1天至成年）大鼠视神经中细胞外钾离子浓度（[K+]o）的活动依赖性变化。[K+]o随最佳刺激频率升高的最大水平取决于年龄：在1至3天大的视神经中，平均最大诱发[K+]o为17.2微摩尔/升，在成年神经中为9.8微摩尔/升。在未成熟视神经中观察到的[K+]o上限，对于哺乳动物中枢神经系统结构而言是独特的高值，可能是由于诱发的钾离子释放速率相对增加所致。
