Ransom B R, Yamate C L, Connors B W
J Neurosci. 1985 Feb;5(2):532-5. doi: 10.1523/JNEUROSCI.05-02-00532.1985.
Activity-dependent shrinkage of extracellular space (ECS) is described in a simple model of the mammalian central nervous system, the rat optic nerve. In response to neural activation, the ECS of the mature nerve rapidly and reversibly decreases by as much as 20%. Activity-dependent ECS shrinkage is not present in neonatal nerves but develops over the first 2 weeks of life, roughly coincident with the appearance of glial cells in this structure. These and other observations suggest that activity-dependent ECS shrinkage results from fluid and electrolyte movements into glial cells.
在哺乳动物中枢神经系统的一个简单模型——大鼠视神经中，描述了细胞外空间（ECS）的活动依赖性收缩。响应神经激活，成熟神经的ECS会迅速且可逆地减少多达20%。新生神经中不存在活动依赖性ECS收缩，但在出生后的前2周内会逐渐形成，大致与该结构中胶质细胞的出现时间一致。这些以及其他观察结果表明，活动依赖性ECS收缩是由于液体和电解质向胶质细胞移动所致。
