Plotnick G D, Kelemen M H, Garrett R B, Randall W, Fisher M L
South Med J. 1982 May;75(5):565-9. doi: 10.1097/00007611-198205000-00015.
This prospective evaluation of 55 consecutive patients, aged 60 years or older, admitted in 1977-1978 to a community hospital coronary care unit for treatment of cardiogenic pulmonary edema, examines morality during hospitalization and during the subsequent one-year follow-up. Their treatment was based on clinical criteria, without the "advantage" of Swan-Ganz catheters and before widespread use of vasodilators for severe congestive heart failure. Multiple clinical and laboratory features were reviewed to determine possible prognostic clues. The nine patients who died during the initial hospitalization provided several clues to immediate mortality, including admission systolic blood pressure of less than 150 mm Hg, dyspnea for more than four hours, and peak creatine kinase values greater than 1,000 IU/L. The study identified high-risk patients who may benefit from more aggressive in-hospital therapy. The one-year mortality among the 46 patients discharged from the hospital was high (43%). Most noninvasive methods were not useful in attempting to predict one-year survival. The important question of whether newer therapeutic methods including vasodilators will favorably alter the relatively poor long-term prognosis in the elderly needs further study.
这项前瞻性评估连续纳入了1977年至1978年间入住一家社区医院冠心病监护病房接受心源肺水肿治疗的55例60岁及以上患者,研究了其住院期间及随后一年随访期内的死亡率。他们的治疗基于临床标准,当时尚无Swan-Ganz导管的“优势”,且血管扩张剂尚未广泛用于重度充血性心力衰竭。回顾了多项临床和实验室特征以确定可能的预后线索。最初住院期间死亡的9例患者提供了一些即时死亡的线索,包括入院时收缩压低于150 mmHg、呼吸困难超过4小时以及肌酸激酶峰值大于1000 IU/L。该研究确定了可能从更积极的住院治疗中获益的高危患者。出院的46例患者的一年死亡率很高(43%)。大多数非侵入性方法在预测一年生存率方面并无用处。包括血管扩张剂在内的新治疗方法是否会有利地改变老年人相对较差的长期预后这一重要问题尚需进一步研究。