Cohen R D, Bateman E D, Potgieter P D
S Afr Med J. 1982 May 22;61(21):803.
Aspirin and other inhibitors of prostaglandin synthetase are known to precipitate bronchospasm in sensitive individuals. We describe a 42-year-old patient with mild asthma who had a near-fatal attack of bronchospasm and required intermittent positive pressure ventilation and resuscitation following ingestion of a single tablet of flurbiprofen (Froben; Boots). When prescribing such agents, an appropriate history should be taken, and when asthma or hypersensitivity to related drugs is suspected, oral challenge with a small test dose and administration of the first dose under supervision are essential.
已知阿司匹林和其他前列腺素合成酶抑制剂可使敏感个体发生支气管痉挛。我们描述了一名42岁的轻度哮喘患者，该患者在服用一片氟比洛芬（Froben；Boots公司生产）后发生了近乎致命的支气管痉挛发作，需要间歇性正压通气和复苏。在开具此类药物处方时，应了解适当的病史，当怀疑有哮喘或对相关药物过敏时，进行小剂量口服激发试验并在监督下给予首剂药物至关重要。
