Kosturkov G, Staneva-Stoianova M, Mileva Zh
Vutr Boles. 1980;19(1):50-3.
The incidence and clinical characteristics of hypersensitivity to acetysal were followed up in 529 patients with bronchial asthma. Manifestation of acetysal hypersensitivity was found in 46 patients (8.69%). It was manifested with bronchospasm in 78.25 per cent of the cases, in 23.91 per cent it was accompanied by skin alterations. Individuaal skin alterations were found in 21.73 per cent of the asthmatic patients with acetysal hypersensitivity. No allergic shock manifestations were observed. In 97.76 per cent of the patients with bronchial asthma and hypersensitivity to acetysal, hypersensitivity to some other medicaments was also found: analgin, analgesics of phenylbutazolon group (butadion, rheopyrin), indomethazin, antibiotics.
对529例支气管哮喘患者随访了对乙酰水杨酸过敏的发生率及临床特征。46例患者（8.69%）出现乙酰水杨酸过敏表现。78.25%的病例表现为支气管痉挛，23.91%伴有皮肤改变。在对乙酰水杨酸过敏的哮喘患者中，21.73%出现了个体皮肤改变。未观察到过敏性休克表现。在97.76%的支气管哮喘且对乙酰水杨酸过敏的患者中，还发现对其他一些药物过敏：安乃近、保泰松类镇痛药（布他酮、瑞吡啉）、消炎痛、抗生素。
