链球菌溶血素O诱导溶血的早期和晚期事件。

Early and late events in streptolysin-O induced hemolysis.

作者信息

Fehrenbach F J, Schmidt C M, Huser H

出版信息

Toxicon. 1982;20(1):233-8. doi: 10.1016/0041-0101(82)90207-0.

Abstract

Treatment of erythrocytes with activated Streptolysin (SLO) resulted in a "swelling" of the target cells. The mean cell volume (MCV) of toxin treated human - sheep - and rabbit red blood cells increased by about 15% of the original value as measured in the Coulter Counter apparatus. Release of hemoglobin was influenced by the addition of high molecular weight colloids. In contrast ATP release was independent of the osmolarity and started before an increase in MCV was observed. The experiments indicated that "colloid osmotic lysis" is involved in SLO induced hemolysis.

摘要

用活化的链球菌溶血素（SLO）处理红细胞会导致靶细胞“肿胀”。在库尔特计数器装置中测量，经毒素处理的人、羊和兔红细胞的平均细胞体积（MCV）增加了约为原始值的15%。血红蛋白的释放受高分子量胶体添加的影响。相比之下，ATP的释放与渗透压无关，且在观察到MCV增加之前就开始了。实验表明，“胶体渗透溶解”参与了SLO诱导的溶血过程。