来自蜂房芽孢杆菌的肺泡溶素诱导人粒细胞生成白三烯。
Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.
作者信息
Bremm K D, Brom H J, Alouf J E, König W, Spur B, Crea A, Peters W
出版信息
Infect Immun. 1984 Apr;44(1):188-93. doi: 10.1128/iai.44.1.188-193.1984.
Abstract
We investigated the effect of alveolysin on human granulocytes. Alveolysin is an exoprotein produced by Bacillus alvei and belongs to the group of sulfhydryl-activated cytolysins. Other members of this group are streptolysin O and theta-toxin from Clostridium perfringens. It is demonstrated that alveolysin leads to leukotriene generation from human granulocytes, which exert chemotactic (leukotriene B4) and slow-reacting substance (leukotriene C4, D4, and E4) activity under sublytic concentrations.
摘要
我们研究了肺泡溶素对人粒细胞的作用。肺泡溶素是由蜂房芽孢杆菌产生的一种外蛋白，属于巯基激活细胞毒素类。该类的其他成员有链球菌溶血素O和产气荚膜梭菌的θ毒素。已证明肺泡溶素可导致人粒细胞产生白三烯，在亚裂解浓度下，这些白三烯具有趋化活性（白三烯B4）和慢反应物质活性（白三烯C4、D4和E4）。
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