Byshevskiĭ A Sh, Sokolovskiĭ S R
Vopr Med Khim. 1982 Mar-Apr;28(2):30-4.
Phosphatidylserine containing anticoagulant and heparin mutually increased their anticoagulating activity under conditions of simultaneous treatment in vitro and in vivo. The rate of the potentiation effect depended on a dosage and, apparently, on the ratio of these anticoagulants. The lipid did not react with heparin as shown by spectrophotometric and gel filtration methods as well as by extraction of 131I-phosphatidylserine with chloroform and sedimentation by means of high speed centrifugation. The data obtained suggest that the potentiating effect of the anticoagulants was not due to formation of a complex exhibiting new properties but was caused by effects of these substances at various steps of blood coagulation process.
在体外和体内同时处理的条件下，含磷脂酰丝氨酸的抗凝剂和肝素相互增强了它们的抗凝活性。增强作用的速率取决于剂量，显然还取决于这些抗凝剂的比例。通过分光光度法、凝胶过滤法以及用氯仿萃取131I - 磷脂酰丝氨酸并通过高速离心沉降表明，该脂质与肝素不发生反应。所获得的数据表明，抗凝剂的增强作用不是由于形成了具有新特性的复合物，而是由这些物质在血液凝固过程的各个步骤中的作用所引起的。
