Byshevskiĭ A Sh, Sokolovskiĭ S R
Biull Eksp Biol Med. 1982 Dec;94(12):23-5.
It was shown in experiments on rats that heparin and phosphatidylserine-containing anticoagulant increase the animals' tolerance to thromboplastin administration to the blood flow. This is manifested by a considerable lowering of the death rate and restriction of fibrinogen consumption caused by thromboplastin. It was ascertained that the protective effects of heparin and phosphatidylserine are drastically potentiated during combined administration, apparently because of the influence of the anticoagulants on different stages of fibrin formation.
在对大鼠的实验中发现,肝素和含磷脂酰丝氨酸的抗凝剂可提高动物对向血流中注入凝血活酶的耐受性。这表现为死亡率显著降低以及凝血活酶引起的纤维蛋白原消耗受限。已确定,肝素和磷脂酰丝氨酸联合给药时,其保护作用会大幅增强,这显然是由于抗凝剂对纤维蛋白形成的不同阶段产生了影响。