Lindemayr W
Z Hautkr. 1982 Feb 1;57(3):162-76.
After reviewing the predisposing factors for venous leg thrombosis prophylactic attempts for patients carrying a continuous risk of thromboembolism and for patients with transient hazards (e.g. after operations) are discussed. Mobilisation with non-elastic bandages and low-dose-heparin in combination with dihydroergotamine is recommended for short term prophylaxis. The unreliability of clinical diagnostic criterias ("thrombosis signs") is pointed out. So additional apparative diagnostic trials are necessary; their values are critically discussed. With certain limitations X-ray phlebography has been proved to be the method of reference. 131 iodine fibrinogen uptake test is recommended best for the detection of calf vein thrombosis. The Doppler sonography is indicated for the detection of pelvic vein thrombosis. Isotope phlebography of the pelvic veins is evaluated, supporting additional information about pulmonary perfusion defects. Due to various contraindications (age, localisation of thrombi, age of thrombi etc.) only a minority of patients with venous thromboses of the lower limbs can be treated by thrombectomy or fibrinolysis, which are regarded as methods of the first choice. So for the vast majority only conservative treatment is feasibly including mobilisation with compression aids and ankle joint exercises for bedridden patients. Direct or indirect anticoagulations seems not to be necessary for patients with calf vein thrombosis, but is indicated for thrombotic affections of the femoral and pelvic veins. Anticoagulation treatment is always combined with compression therapy and mobilisation, except for some patients who had been immobilized before the clinical attendance. The treatment of superficial thrombophlebitis consists of incision and extrusion of thrombotic masses, antiphlogistic drugs and mobilisation with compression bandages.
在回顾了下肢静脉血栓形成的诱发因素后,讨论了对有持续血栓栓塞风险的患者以及有短暂风险的患者(如术后)进行预防的措施。对于短期预防,建议使用非弹性绷带进行活动,并联合低剂量肝素和双氢麦角胺。指出了临床诊断标准(“血栓形成体征”)的不可靠性。因此,需要进行额外的仪器诊断试验,并对其价值进行了批判性讨论。在一定限制条件下,X线静脉造影已被证明是参考方法。131碘纤维蛋白原摄取试验最适合用于检测小腿静脉血栓形成。多普勒超声检查适用于检测盆腔静脉血栓形成。对盆腔静脉同位素静脉造影进行了评估,以支持有关肺灌注缺损的更多信息。由于各种禁忌症(年龄、血栓部位、血栓形成时间等),只有少数下肢静脉血栓形成的患者可以通过血栓切除术或纤维蛋白溶解术治疗,这两种方法被视为首选方法。因此,对于绝大多数患者,可行的治疗方法只有保守治疗,包括对卧床患者使用加压辅助器具进行活动和踝关节运动。对于小腿静脉血栓形成的患者,似乎不需要直接或间接抗凝,但对于股静脉和盆腔静脉的血栓形成则需要抗凝。除了一些在就诊前已长期卧床的患者外,抗凝治疗总是与加压治疗和活动相结合。浅静脉血栓形成的治疗包括切开并挤出血栓块、使用抗炎药物以及使用加压绷带进行活动。