Martynov A I, Grinevich A S, Korshunov V M, Pinegin B V
Zh Mikrobiol Epidemiol Immunobiol. 1982 Jan(1):48-54.
Changes in the microflora of the large and small intestines in mice and guinea pigs after the oral administration of canamycin (a hardly absorbable antibiotic) and ampiox (an easily absorbable antibiotic) in different doses. The administration of these antibiotics in different doses (therapeutic, subtherapeutic and over therapeutic) led to an increase in the number of opportunistic microorganisms and the contamination of the small intestine by these organisms. These changes were also well pronounced in guinea pigs, normally having no enterobacteria. After the administration of the antibiotics was stopped, opportunistic microorganisms were gradually eliminated from the small intestine. The rate of decontamination depended on the administered dose of the antibiotic: the higher the dose was the longer the process of the decontamination of the small intestine lasted. An increase in the amount of opportunistic microbes in the large intestine and the decontamination of the small intestine occurred simultaneously with the decrease in the amount of lactobacilli and bifidobacteria in both the small and large intestines.
小鼠和豚鼠口服不同剂量的卡那霉素（一种难吸收的抗生素）和氨比西林（一种易吸收的抗生素）后，其大肠和小肠微生物区系的变化。给予不同剂量（治疗剂量、亚治疗剂量和超治疗剂量）的这些抗生素会导致机会性微生物数量增加，以及小肠被这些微生物污染。这些变化在通常不含肠杆菌的豚鼠中也很明显。停止使用抗生素后，机会性微生物逐渐从小肠中清除。去污速率取决于抗生素的给药剂量：剂量越高，小肠去污过程持续的时间越长。大肠中机会性微生物数量的增加和小肠的去污与小肠和大肠中乳酸杆菌和双歧杆菌数量的减少同时发生。
