精神分裂症的遗传模型。

Genetic models of schizophrenia.

作者信息

Baron M

出版信息

Acta Psychiatr Scand. 1982 Apr;65(4):263-75. doi: 10.1111/j.1600-0447.1982.tb00846.x.

DOI:10.1111/j.1600-0447.1982.tb00846.x

Abstract

Multiple threshold models of inheritance are applied to a large sample of Franz Kallmann's (1938) pedigree data on schizophrenia. Paranoid and nonparanoid subtypes are represented in the models at different thresholds on a continuum of genetic-environmental liability. Single major locus and multifactorial-polygenic inheritance are ruled out as modes of transmission. These findings suggest that the paranoid-non-paranoid dichotomy cannot be used as a genetic threshold determinant in the population studied.

摘要

将多种遗传阈值模型应用于弗朗茨·卡尔曼（1938年）关于精神分裂症的大量系谱数据样本。偏执型和非偏执型亚型在模型中以遗传-环境易感性连续体上的不同阈值表示。单基因座和多基因遗传作为遗传模式被排除。这些发现表明，在所研究的人群中，偏执型-非偏执型二分法不能用作遗传阈值决定因素。