Jonassen F, Granerus G, Wetterqvist H
Acta Obstet Gynecol Scand. 1976;55(4):297-304. doi: 10.3109/00016347609158501.
The urinary excretion of histamine and its metabolites methylhistamine (MeHi) and methylimidazoleacetic acid (MeImAA) was measured during the menstrual cycle in nine healthy women, one allergic woman and three non-pregnant women with anovulatory regular cycles. Simultaneous urinary analyses of luteinizing hormone (LH) and total estrogens were performed. The healthy women showed individual variations in the excretion of histamine, MeHi and MeImAA. This observation has been interpreted as an expression of minor individual differences in the catabolism of histamine. At midcycle an increase in the urinary excretion of histamine metabolites was sometimes evident and a statistically significant correlation could be established between MeHi and estrogen in urine. These results may support previous findings of histamine release by estrogens in uterine tissue but may also reflect an elevated histamine formation. The allergic woman excreted constantly increased amounts of histamine and its metabolites, especially when her allergic symptoms became aggravated pre-menstrually. She did not exhibit any change in MeImAA excretion at midcycle but the MeHi-excretion varied with the excretion of estrogens in the urine. The subjects with anovulatory menstrual cycles had low values of histamine and metabolites although within the normal variations.
在月经周期中，对9名健康女性、1名过敏女性和3名无排卵规律周期的非孕女性的组胺及其代谢产物甲基组胺（MeHi）和甲基咪唑乙酸（MeImAA）的尿排泄量进行了测量。同时对促黄体生成素（LH）和总雌激素进行了尿分析。健康女性在组胺、MeHi和MeImAA的排泄方面表现出个体差异。这一观察结果被解释为组胺分解代谢中微小个体差异的一种表现。在月经周期中期，组胺代谢产物的尿排泄量有时会明显增加，并且尿液中MeHi与雌激素之间可以建立统计学上的显著相关性。这些结果可能支持先前关于雌激素在子宫组织中释放组胺的研究结果，但也可能反映出组胺生成增加。该过敏女性持续排泄出增加量的组胺及其代谢产物，尤其是在经前过敏症状加重时。她在月经周期中期MeImAA排泄量没有任何变化，但MeHi排泄量随尿液中雌激素的排泄而变化。无排卵月经周期的受试者组胺及其代谢产物的值较低，尽管在正常变化范围内。
