Granerus G, Weinfeld A, Westin J
Agents Actions. 1983 Apr;13(2-3):251-5. doi: 10.1007/BF01967345.
Histamine metabolism was investigated in three patients with chronic granulocytic leukaemia (CGL) during symptoms suspected to be caused by histamine release. Plasma histamine levels were excessively high compared with periods when the patients were symptomless or with CGL patients without such symptoms. The patients seemed to be adapted to high plasma histamine levels as the symptoms were not typically systemic in nature, but rather localized phenomena like oedema and pruritus in the extremities. Also CGL patients without symptoms showed abnormally high plasma histamine concentrations, which were significantly related to the whole blood histamine concentration. The possibility must be considered that part of the plasma histamine increase is artificial due to rupture of the basophils during the blood collection procedure.
在三名慢性粒细胞白血病（CGL）患者出现疑似由组胺释放引起的症状期间，对其组胺代谢进行了研究。与患者无症状时期或无此类症状的CGL患者相比，血浆组胺水平过高。这些患者似乎适应了高血浆组胺水平，因为症状并非典型的全身性，而是局部现象，如肢体水肿和瘙痒。无症状的CGL患者血浆组胺浓度也异常高，这与全血组胺浓度显著相关。必须考虑到，血浆组胺增加的部分原因可能是采血过程中嗜碱性粒细胞破裂导致的人为因素。
