The behaviour of immunoglobulins in children and adolescents hyposensitized for pollinosis and pollen asthma.

The levels of immunoglobulins E, G, A and M in pre- and post-hyposensitized sera were determined in 28 children and adolescents (aged from 5 to 19 years) with pollinosis and pollen asthma. "Pollinex" was used for hyposensitization. The treatment was begun before the pollen season, successively over 1 to 3 years. The following results were obtained IgE increased in 46.7% of the patients, IgG and IgA were normal in 75% and 85.7% respectively. IgG increased after hyposensitization, but the values remained within normal limits. IgM exceeded normal values in 53.6% of the patients before treatment. Following successive hyposensitization, a statistically significant increase in IgE and a statistically insignificant increase in IgG were observed. IgA values increased only slightly.