Urbanek R, Kuhn W, Binder U
Dtsch Med Wochenschr. 1983 Sep 23;108(38):1433-7. doi: 10.1055/s-2008-1069763.
Hyposensitization was undertaken in 26 children, aged 4-15 years, with proven sensitivity to grass and wheat pollen, in some orally (ten), in others parenterally (16), for two years before the start of the season. The administered cumulative dose with oral hyposensitization was 1,750,000 PNU (protein nitrogen units), corresponding to 3,500,000 NU (Noon units), and on parenteral sensitization 1,550 PNU, corresponding to 3,100 NU. A symptoms score was registered daily during the pollen season. It showed fewer symptoms in those with parenteral hyposensitization, although subjective assessment of the success of treatment did not indicate any difference between the two groups. Oral hyposensitization produced a higher IgE and a lower IgG immune response. Systemic side-effects were noted in half of those after oral but none after parenteral hyposensitization. Measured by side-effects, the cumulative dose and expense, the effectiveness of oral hyposensitization is inferior to parenteral administration.
对26名4至15岁已证实对草花粉和小麦花粉过敏的儿童进行了脱敏治疗，在花粉季节开始前两年，部分儿童采用口服脱敏（10名），部分采用注射脱敏（16名）。口服脱敏的累积给药剂量为1750000蛋白氮单位（PNU），相当于3500000努恩单位（NU）；注射脱敏的剂量为1550 PNU，相当于3100 NU。在花粉季节期间每天记录症状评分。结果显示，注射脱敏的儿童症状较少，尽管对治疗效果的主观评估表明两组之间没有差异。口服脱敏产生了较高的IgE和较低的IgG免疫反应。口服脱敏的儿童中有一半出现全身副作用，而注射脱敏的儿童则未出现。从副作用、累积剂量和费用来看，口服脱敏的效果不如注射给药。
