Bernauer W, Wolf K
Arch Int Pharmacodyn Ther. 1978 Aug;234(2):257-69.
In isolated perfused guinea-pig hearts decrease of coronary flow, release of creatine kinase (CK), severe arrhythmias and early standstill were produced by intracoronary application of plastic microspheres. 1 X 10(-9) g verapamil/ml perfusion fluid significantly decreased the CK release from these "ischemic" hearts. With 1 X 10(-8) g/ml a significant increase of the survival times was obtained. Dexamethasone strongly depressed the enzyme release from the coronary obstructed hearts. The survival times, however, were not prolonged. Isoproterenol significantly shortened the survival times. Very low concentrations decreased the CK release, whereas higher concentrations themselves provoked an enzyme release.
在离体灌注豚鼠心脏中，冠状动脉内应用塑料微球可导致冠状动脉血流量减少、肌酸激酶（CK）释放、严重心律失常和早期停搏。灌注液中加入1×10⁻⁹g维拉帕米/毫升可显著降低这些“缺血”心脏的CK释放。加入1×10⁻⁸g/毫升可显著延长存活时间。地塞米松强烈抑制冠状动脉阻塞心脏的酶释放。然而，存活时间并未延长。异丙肾上腺素显著缩短存活时间。极低浓度可降低CK释放，而较高浓度本身会引发酶释放。
