Johnston J R, McCaughey W, Moore J, Dundee J W
Anaesthesia. 1982 Jan;37(1):26-32. doi: 10.1111/j.1365-2044.1982.tb00989.x.
The H2-receptor antagonist cimetidine was used as a pre-operative antacid in 64 women scheduled for elective Caesarean section. All were given cimetidine 400 mg 90-215 minutes before induction, with 20 of them having an extra 400 mg dose the previous night. The intragastric pH at induction of anaesthesia was reliably above 2.5 if the treatment was given 90-150 minutes beforehand. The volume of gastric contents was reduced when compared with a control series of women receiving either no pre-operative antacid or 30 ml magnesium trisilicate mixture BPC. No adverse effects on mothers or infants were detected.
H2受体拮抗剂西咪替丁被用作64例计划行择期剖宫产手术的女性患者的术前抗酸剂。所有患者在诱导麻醉前90 - 215分钟给予400毫克西咪替丁，其中20例患者在前一晚额外给予400毫克剂量。如果在诱导麻醉前90 - 150分钟进行治疗，麻醉诱导时胃内pH值可稳定高于2.5。与未接受术前抗酸剂或接受30毫升硅酸镁混合物BPC的对照组女性相比，胃内容物量减少。未检测到对母亲或婴儿的不良影响。
