雷尼替丁会影响口服咪达唑仑的吸收。
Ranitidine influences the uptake of oral midazolam.
作者信息
Elwood R J, Hildebrand P J, Dundee J W, Collier P S
出版信息
Br J Clin Pharmacol. 1983 Jun;15(6):743-5. doi: 10.1111/j.1365-2125.1983.tb01559.x.
Abstract
In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in higher plasma levels for the first 6 h after taking midazolam. This was accompanied by a greater soporific effect.
摘要
在一项针对志愿者的随机交叉研究中，口服15毫克咪达唑仑后24小时内，分别在未用药或雷尼替丁治疗24小时后，对血浆咪达唑仑水平进行了评估。给予H2受体阻滞剂显著提高了苯二氮䓬类药物的生物利用度，并导致服用咪达唑仑后的前6小时血浆水平更高。这伴随着更强的催眠效果。
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Midazolam: a water-soluble benzodiazepine. Studies in volunteers.咪达唑仑：一种水溶性苯二氮䓬类药物。志愿者研究。
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Br J Clin Pharmacol. 1982 Aug;14(2):207-11. doi: 10.1111/j.1365-2125.1982.tb01963.x.
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