Cantekin E I, Doyle W J, Bluestone C D
Ann Otol Rhinol Laryngol. 1982 Mar-Apr;91(2 Pt 1):179-84. doi: 10.1177/000348948209100213.
Employing inflation-deflation and forced-response tests, the eustachian tube (ET) function was evaluated in six adult human subjects with traumatic perforation of the tympanic membrane and otherwise negative otologic histories; and 15 juvenile or adult rhesus monkeys with freshly created myringotomy perforations of the tympanic membrane and otherwise documented normal middle ears. The study findings demonstrated that the rhesus monkey ET functions as a scaled down model of the ET of man, exhibiting a shorter tubal dilation duration and a lesser capacity to pass air. When ET function in the two species was compared using a dimensionless measure expressing the tubal dilation efficiency, the operational biomechanics of both systems were found to be almost identical. These observed functional homologies between man and the rhesus monkey ET systems suggest that the rhesus monkey is a suitable animal model in which to study the pathogenesis of otitis media with effusion, stemming from ET dysfunction.
采用充胀-消胀和强制反应测试，对6名鼓膜外伤性穿孔且耳科病史无其他异常的成年人类受试者，以及15只鼓膜有新鲜造孔且中耳经记录无其他异常的幼年或成年恒河猴的咽鼓管（ET）功能进行了评估。研究结果表明，恒河猴的咽鼓管功能作为人类咽鼓管的缩小模型，其管腔扩张持续时间较短，通气能力较小。当使用表达咽鼓管扩张效率的无量纲指标比较两个物种的咽鼓管功能时，发现两个系统的操作生物力学几乎相同。在人类和恒河猴咽鼓管系统之间观察到的这些功能同源性表明，恒河猴是研究由咽鼓管功能障碍引起的分泌性中耳炎发病机制的合适动物模型。
