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同期颈动脉和冠状动脉重建术。

Concomitant carotid and coronary artery reconstruction.

作者信息

Craver J M, Murphy D A, Jones E L, Curling P E, Bone D K, Smith R B, Perdue G D, Hatcher C R, Kandrach M

出版信息

Ann Surg. 1982 Jun;195(6):712-20. doi: 10.1097/00000658-198206000-00006.

Abstract

Data are presented on 68 patients who underwent concomitant carotid endarterectomy (CE) and coronary artery bypass surgery (CAB) at Emory University Hospital from January 1974 to February 1981. This group is then compared with a randomly selected, matched population without known carotid disease who underwent CAB alone. Asymptomatic bruit was the reason for investigation in 40 patients (59%); another 23 patients (34%) experienced transient cerebral ischemic attacks (TIAs); and five patients (7%) had TIA and prior stroke. Carotid stenoses (>75% luminal narrowing) were demonstrated as follows: isolated left, 24 patients; isolated right, 27 patients; and bilateral lesions, 16 patients. One patient had innominate artery stenosis. Associated total occlusion of one or both vertebral arteries was demonstrated in six patients. Ninety-seven per cent of patients had disabling angina pectoris prior to operation; the angina was unstable in 57%, 15% had congestive heart failure, and 54% had had at least one prior myocardial infarction (MI). Single-vessel coronary disease was present in 12.5% of patients, double in 37.5%, triple in 41.1%, and left main stenosis in 9%; 43% of patients had abnormal ventricular contractility. CE was performed on 67 patients (36 left and 31 right); aortocarotid bypass was performed on one. The CE procedures were performed immediately prior to the sternotomy for CAB under the same anesthesia. CAB consisted of single bypass in eight patients (11.8%); double in 16 patients (23.5%); triple in 22 patients (32.4%); and quadruple or more in 22 patients (32.4%) (mean = 2.9 grafts per patient). There was no hospital mortality. Perioperative MI occurred in 2.0% and stroke with residual deficit in 1.3%. Cumulative survival is 98.5% at two years. Sixty-three patients (92%) reported improvement or elimination of anginal symptoms after operation. Rehospitalization for stroke was necessary in 3.7% patients. Postoperative activity levels are; self-care only, 3.9%; normal daily activity only, 17.6%; moderate exercise capability, 45%; and vigorous exercise capability, 33%. Comparison was made with a group of 84 randomly selected patients who underwent CAB alone during the same time interval. Data revealed no significant difference between the groups regarding sex, angina subset, ventricular function, coronary anatomy, vessels grafted, perioperative stroke or MI, mortality, or postoperative activity capability. Older age (59.8 vs. 55.6, p < 0.01) and less complete coronary revascularization possible (66 vs. 84%, p < 0.05) in the CECAB group were the only significant differences. Carotid stenosis co-existing in patients requiring CAB should be concomitantly corrected with the same risk and results expected from CAB alone.

摘要

本文呈现了1974年1月至1981年2月间在埃默里大学医院接受同期颈动脉内膜切除术(CE)和冠状动脉旁路移植术(CAB)的68例患者的数据。然后将该组患者与随机选取的、无已知颈动脉疾病且仅接受CAB的匹配人群进行比较。40例患者(59%)因无症状性杂音接受检查;另外23例患者(34%)经历过短暂性脑缺血发作(TIA);5例患者(7%)有TIA且既往有卒中史。颈动脉狭窄(管腔狭窄>75%)情况如下:孤立性左侧狭窄24例;孤立性右侧狭窄27例;双侧病变16例。1例患者有无名动脉狭窄。6例患者显示一侧或双侧椎动脉完全闭塞。97%的患者术前有失能性心绞痛;其中57%为不稳定型心绞痛,15%有充血性心力衰竭,54%至少有过一次心肌梗死(MI)。12.5%的患者为单支冠状动脉疾病,37.5%为双支,41.1%为三支,9%为左主干狭窄;43%的患者心室收缩功能异常。67例患者接受了CE(36例左侧,31例右侧);1例接受了主动脉 - 颈动脉旁路移植术。CE手术在与CAB相同的麻醉下于胸骨切开术前立即进行。CAB包括单支旁路移植术8例(11.8%);双支16例(23.5%);三支22例(32.4%);四支及以上22例(32.4%)(平均每位患者2.9支移植血管)。无医院死亡病例。围手术期MI发生率为2.0%,有残留神经功能缺损的卒中发生率为1.3%。两年累积生存率为98.5%。63例患者(92%)术后报告心绞痛症状改善或消失。3.7%的患者因卒中需再次住院。术后活动水平如下:仅能自理,3.9%;仅能进行正常日常活动,17.6%;有中等运动能力,45%;有剧烈运动能力,33%。与同期随机选取的84例仅接受CAB的患者组进行比较。数据显示两组在性别、心绞痛亚组、心室功能、冠状动脉解剖、移植血管数量、围手术期卒中或MI、死亡率或术后活动能力方面无显著差异。CECAB组患者年龄较大(59.8岁对55.6岁,p<0.01)且可能的冠状动脉血运重建不完全(66%对84%,p<0.05)是仅有的显著差异。需要CAB的患者并存的颈动脉狭窄应在相同风险下同时纠正,且预期结果与单纯CAB相同。

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