Krohn I T, Cooper D R, Bassett J G
Arch Surg. 1982 Jun;117(6):760-3. doi: 10.1001/archsurg.1982.01380300008003.
Radical mastectomy with wide skin excision, ultrathin skin flaps, and autogenous skin grafts was a selected treatment of 45 women with curable breast cancer. A similar group of 45 women were treated by radical mastectomy with less wide skin excision, primary wound closure, and without ultrathin skin flaps. The two patient series were comparable in clinical disease staging, age, axillary node metastases, and frequency of adjunctive chest-wall irradiation. Retrospective chart reviews of the two patient series and statistical analyses indicated that five-and ten-year survival and local recurrences were comparable, but wound complications, hospital stays, and subsequent lymphedema were significantly greater in the series with thinner skin flaps. We recommend that routine use of ultrathin flaps be abandoned for treatment of breast cancer.
采用广泛皮肤切除、超薄皮瓣和自体皮肤移植的根治性乳房切除术是45例可治愈乳腺癌女性患者的一种选定治疗方法。另一组45例女性患者接受了皮肤切除范围较小、一期伤口闭合且无超薄皮瓣的根治性乳房切除术。这两组患者在临床疾病分期、年龄、腋窝淋巴结转移情况以及辅助胸壁放疗频率方面具有可比性。对这两组患者的回顾性病历审查和统计分析表明，两组患者的5年和10年生存率以及局部复发情况相当，但超薄皮瓣组的伤口并发症、住院时间和随后的淋巴水肿明显更多。我们建议在乳腺癌治疗中放弃常规使用超薄皮瓣。
