Schwarz G, Savko P
Bioelectromagnetics. 1982;3(1):25-8. doi: 10.1002/bem.2250030107.
Dielectric constant and loss of alamethicin in solvents of various degrees of lipophilicity (namely mixtures of n-octanol and dioxane) have been measured at frequencies from 5 kHz to 50 MHz. By means of a conventional Cole-Cole approach, dielectric properties were evaluated to obtain information about the structural and dipolar properties of the peptide in view of its function as a voltage-dependent pore former in membranes. The results for a pure octanol solvent (together with an apparent molecular weight determined by ultracentrifugation) indicate the existence of primarily monomeric particles of quite elongated shape and of comparatively high dipole moment. Adding dioxane was found to yield considerable aggregation and a decrease of polarity.
已在5千赫兹至50兆赫兹的频率范围内测量了丙甲菌素在各种亲脂性程度的溶剂（即正辛醇和二氧六环的混合物）中的介电常数和损耗。通过传统的科尔-科尔方法，鉴于该肽作为膜中电压依赖性成孔剂的功能，对介电特性进行了评估，以获取有关该肽的结构和偶极特性的信息。纯辛醇溶剂的结果（以及通过超速离心法测定的表观分子量）表明，主要存在形状相当细长且偶极矩相对较高的单体颗粒。发现添加二氧六环会导致大量聚集并降低极性。
