Schwarz G, Savko P, Jung G
Biochim Biophys Acta. 1983 Mar 9;728(3):419-28. doi: 10.1016/0005-2736(83)90514-x.
The dielectric dispersion of trichotoxin A40 in solvents of diverse lipophilicity (i.e. n-octanol, dioxane and mixtures of these) has been measured between 100 kHz and 50 MHz. In pure octanol also the weight average molecular weight and the concentration dependence of the circular dichroism spectrum were determined. An analysis of the data leads to the conclusion that in octanol an appreciable amount of the solute exists as single monomeric particles which are about 30 A long and 12.5 A in diameter. There is a dipole moment parallel to the long axis. In addition the evidence points at the presence of small aggregates (mainly dimers and trimers) formed by some kind of head-to-tail association. Evidently dioxane added to octanol favors a different structure of the trichotoxin monomer. It is apparently involved in another aggregation process resulting in aggregates of large size but comparatively low dipole moments.
已在100千赫至50兆赫之间测量了曲毒素A40在不同亲脂性溶剂（即正辛醇、二氧六环以及它们的混合物）中的介电色散。在纯辛醇中，还测定了重均分子量和圆二色光谱的浓度依赖性。对数据的分析得出结论，在辛醇中，相当数量的溶质以单个单体颗粒形式存在，这些颗粒长约30埃，直径为12.5埃。存在一个与长轴平行的偶极矩。此外，有证据表明存在由某种头对尾缔合形成的小聚集体（主要是二聚体和三聚体）。显然，添加到辛醇中的二氧六环有利于曲毒素单体形成不同的结构。它显然参与了另一种聚集过程，导致形成大尺寸但偶极矩相对较低的聚集体。
