McCune W J, Buckley J A, Belli J A, Trentham D E
Arthritis Rheum. 1982 May;25(5):532-9. doi: 10.1002/art.1780250507.
Treatments with fractionated total lymphoid irradiation (TLI) and cyclophosphamide were evaluated for rats injected with type II collagen. Preadministration of TLI and repeated injections of cyclophosphamide suppressed the severity of arthritis and lowered antibody titers to collagen significantly. TLI initiated at the onset of collagen arthritis decreased humoral and cellular responses to collagen but did not affect the severity of arthritis. These data demonstrate that both TLi and cyclophosphamide are immunosuppressive in an experimentally inducible autoimmune disease.
对注射了II型胶原蛋白的大鼠评估了分次全身淋巴照射（TLI）和环磷酰胺的治疗效果。TLI预处理和环磷酰胺重复注射可抑制关节炎的严重程度，并显著降低针对胶原蛋白的抗体滴度。在胶原蛋白性关节炎发作时开始的TLI可降低对胶原蛋白的体液和细胞反应，但不影响关节炎的严重程度。这些数据表明，TLI和环磷酰胺在实验诱导的自身免疫性疾病中均具有免疫抑制作用。
