Moore W S, Boren C, Malone J M, Roon A J, Eisenberg R, Goldstone J, Mani R
Arch Surg. 1978 Nov;113(11):1352-9. doi: 10.1001/archsurg.1978.01370230142018.
To define the natural history of the asymptomatic, nonstenotic, ulcerative lesion involving the carotid artery bifurcation, the arteriograms and clinical course of 67 patients with 72 asymptomatic ulcerative lesions of the carotid artery were reviewed. The angiographic appearance of ulceration was classified into three groups: minimal (group A), large (group B), and compound (group C). Using life-table methods, the clinical course of these patients was compared between groups and was also compared to a nonrandomized surgically treated group of patients with nonstenotic ulcerative lesions in whom operation was performed for hemispheric or monocular symptoms. There were no significant (P greater than .1) differences in mortality, but the differences in stroke incidence was highly significant (P less than .001). The annual stroke rate, averaged over seven years, was 0.4% per year for group A, 1.47% per year for the surgically treated group, and 12.5% per year for groups B and C. The data indicate that group A ulcers have a benign prognosis, in noticeable contrast to group B and C ulcers which incur a high risk for subsequent stroke.
为明确累及颈动脉分叉处的无症状、无狭窄性溃疡性病变的自然病程，我们回顾了67例患者72处无症状性颈动脉溃疡性病变的动脉造影及临床病程。溃疡的血管造影表现分为三组：轻度（A组）、重度（B组）和复合型（C组）。采用寿命表法，对这些患者组间的临床病程进行了比较，并与一组因半球或单眼症状而接受手术治疗的非狭窄性溃疡性病变患者（非随机分组）进行了比较。死亡率无显著差异（P大于0.1），但中风发生率差异极显著（P小于0.001）。A组七年平均年中风率为每年0.4%，手术治疗组为每年1.47%，B组和C组为每年12.5%。数据表明，A组溃疡预后良好，这与B组和C组溃疡随后发生中风的高风险形成明显对比。
