Zaets T L, Movshev B E, Muzykant L I, Nedoshivina R V, Koriakina I K
Biull Eksp Biol Med. 1982 Apr;93(4):46-9.
Experiments on rats were made to study the action of toxic glycoprotein isolated from burn skin on the lysosomal apparatus of hepatocytes and morphological structure of the liver. It was shown that 2-2.5 h after intraperitoneal injection to normal rats of toxic preparations of varying purity, the animals developed morphological alterations similar to those seen in the liver of the burn animals. At the same time there was an appreciable increase in the percentage of unsedimentable activity of catepsine D of the total one, thereby indicating the toxin-induced injury to the lysosomal apparatus of hepatocytes.
进行了大鼠实验，以研究从烧伤皮肤分离出的毒性糖蛋白对肝细胞溶酶体装置及肝脏形态结构的作用。结果表明，给正常大鼠腹腔注射不同纯度的毒性制剂后2至2.5小时，动物出现了与烧伤动物肝脏相似的形态学改变。与此同时，组织蛋白酶D不可沉降活性占总活性的百分比显著增加，从而表明毒素对肝细胞溶酶体装置造成了损伤。
