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[基于体内和体外生物学实验结果的烧伤皮肤高分子量蛋白质毒性]

[Toxicity of burned skin high molecular weight protein according to the results of biological experiments in vivo and in vitro].

作者信息

Movshev B E, Nedoshivina R V, Koriakina I K

出版信息

Biull Eksp Biol Med. 1980 Oct;90(10):422-5.

PMID:7426703
Abstract

In vivo and in vitro experiments have demonstrated the toxic effect of high-molecular protein isolated from burnt skin extract (BSE) by immunosorption. The toxin preparations cause the death of mice with RES blockade and inhibit the leukocyte migration capacity in culture. It was shown in control experiments that BSE after passage through the immunosorbent fully loses its toxic properties because of toxin binding to insoluble-base-fixed antibodies.

摘要

体内和体外实验均已证明,通过免疫吸附从烧伤皮肤提取物(BSE)中分离出的高分子蛋白质具有毒性作用。这些毒素制剂可导致网状内皮系统(RES)被阻断的小鼠死亡,并抑制培养物中白细胞的迁移能力。对照实验表明,BSE通过免疫吸附剂后,由于毒素与不溶性碱固定抗体结合,其毒性完全丧失。

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