Panzer S, Kronik G, Lechner K, Bettelheim P, Neumann E, Dudczak R
Blood. 1982 Jun;59(6):1348-50.
Levels of glycosylated hemoglobins (GHb) are significantly (p less than 0.0005) lower in patients with hemolytic anemia (n = 20; mean = 3.9% +/- 0.1% SD GHb of total Hb) compared to patients with nonhemolytic anemia (n = 20; mean = 7.0% +/- 0.7% GHb) and normal controls (n = 30; mean = 6.7% +/- 0.7% GHb). A curvilinear correlation between GHb and red cell survival is demonstrable (n = 20;r2 = 0.88; p less than 0.001). Determination of GHb may be useful as a screening test for hemolytic anemia and for the evaluation of the degree of hemolysis, provided that diabetes mellitus can be excluded.
与非溶血性贫血患者（n = 20；糖化血红蛋白平均占总血红蛋白的比例为7.0%±0.7%）和正常对照组（n = 30；糖化血红蛋白平均占总血红蛋白的比例为6.7%±0.7%）相比，溶血性贫血患者（n = 20；糖化血红蛋白平均占总血红蛋白的比例为3.9%±0.1%标准差）的糖化血红蛋白水平显著降低（p<0.0005）。糖化血红蛋白与红细胞存活率之间存在曲线相关性（n = 20；r2 = 0.88；p<0.001）。如果可以排除糖尿病，测定糖化血红蛋白可能有助于溶血性贫血的筛查以及溶血程度的评估。
