Elliott D A, Nelson R W, Feldman E C, Neal L A
Veterinary Medical Teaching Hospital, Davis, CA, USA.
J Am Vet Med Assoc. 1997 Sep 15;211(6):723-7.
To characterize glycosylated hemoglobin (GHb) concentrations in the blood of dogs with disorders that may affect serum glucose or blood GHb concentrations, and to determine whether changes in GHb concentration correlate with changes in control of diabetes in dogs.
Prospective study.
63 healthy dogs, 9 dogs with anemia, 24 dogs with untreated hyperadrenocorticism, 12 dogs with pancreatic beta-cell neoplasia, 23 dogs with newly diagnosed diabetes mellitus, and 77 diabetic dogs treated with insulin.
Control of diabetes in dogs treated with insulin was classified as good or poor on the basis of history, physical examination findings, changes in body weight, and measurement of serum glucose concentrations Sequential evaluations of control were performed and GHb concentration in blood was measured, by means of affinity chromatography, for 5 untreated diabetic dogs before and after initiating insulin treatment, for 10 poorly controlled diabetic dogs before and after increasing insulin dosage, and for 5 diabetic dogs before and after pancreatic islet cell transplantation.
Mean (+/-SD) GHb concentration was 3.3 +/- 0.8% in the blood of healthy dogs. Compared with results from healthy dogs, mean GHb concentration was significantly lower in the blood of dogs with anemia and pancreatic beta-cell neoplasia and significantly higher in the blood of untreated diabetic dogs. Mean GHb concentration was significantly higher in the blood of 46 poorly controlled diabetic dogs, compared with 31 well-controlled diabetic dogs (7.3 +/- 1.8 vs 5.7 +/- 1.7%, respectively). Mean GHb concentration in blood decreased significantly in 5 untreated diabetic dogs after treatment (8.7 +/- 1.9 vs 5.3 +/- 1.9%). Mean GHb concentration in blood also decreased significantly in 10 poorly controlled diabetic dogs after control was improved and in 5 diabetic dogs after they had received a pancreatic islet cell transplant.
Measurement of GHb concentration in blood may assist in monitoring control of diabetes in dogs.
对可能影响血清葡萄糖或血液糖化血红蛋白（GHb）浓度的疾病犬的血液中GHb浓度进行特征描述，并确定GHb浓度的变化是否与犬糖尿病控制情况的变化相关。
前瞻性研究。
63只健康犬、9只贫血犬、24只未经治疗的肾上腺皮质功能亢进犬、12只胰腺β细胞瘤犬、23只新诊断的糖尿病犬以及77只接受胰岛素治疗的糖尿病犬。
根据病史、体格检查结果、体重变化和血清葡萄糖浓度测量，将接受胰岛素治疗的犬的糖尿病控制情况分为良好或不佳。对控制情况进行连续评估，并通过亲和色谱法测量血液中的GHb浓度，测量对象包括5只未经治疗的糖尿病犬在开始胰岛素治疗前后、10只控制不佳的糖尿病犬在增加胰岛素剂量前后以及5只糖尿病犬在胰岛细胞移植前后。
健康犬血液中的平均（±标准差）GHb浓度为3.3±0.8%。与健康犬的结果相比，贫血犬和胰腺β细胞瘤犬血液中的平均GHb浓度显著降低，未经治疗的糖尿病犬血液中的平均GHb浓度显著升高。46只控制不佳的糖尿病犬血液中的平均GHb浓度显著高于31只控制良好的糖尿病犬（分别为7.3±1.8%和5.7±1.7%）。5只未经治疗的糖尿病犬治疗后血液中的平均GHb浓度显著降低（8.7±1.9%对5.3±1.9%）。10只控制不佳的糖尿病犬在控制改善后以及5只糖尿病犬在接受胰岛细胞移植后，血液中的平均GHb浓度也显著降低。
测量血液中的GHb浓度可能有助于监测犬糖尿病的控制情况。
