单克隆丙种球蛋白病中血清阴离子间隙和钠水平的变化。
Changes in serum anion gap and sodium level in monoclonal gammopathies.
作者信息
Nanji A A, Halstead A C
出版信息
Can Med Assoc J. 1982 Jul 1;127(1):32-5.
Abstract
In a group of patients with monoclonal gammopathies a decrease in the serum anion gap was seen with increasing serum concentrations of monoclonal IgG and IgM but not monoclonal IgA. This was probably related to the fact that IgG and IgM are cationic but IgA is a anionic at a physiologic pH. The serum sodium level decreased by 0.7 mmol/l for every increase of 1 g/dl in the serum level of the monoclonal immunoglobulin, likely because of the volume displacement effect of the monoclonal protein.
摘要
在一组单克隆丙种球蛋白病患者中，随着血清中克隆性IgG和IgM浓度的升高，血清阴离子间隙降低，但克隆性IgA则不然。这可能与以下事实有关：在生理pH值下，IgG和IgM呈阳离子性，而IgA呈阴离子性。单克隆免疫球蛋白血清水平每增加1 g/dl，血清钠水平下降0.7 mmol/l，这可能是由于单克隆蛋白的容积置换效应所致。
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