Schnur M J, Appel G B, Karp G, Osserman E P
Ann Intern Med. 1977 Mar;86(3):304-5. doi: 10.7326/0003-4819-86-3-304.
The presence of a low anion gap in patients with multiple myeloma has recently been emphasized. This has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins. We now report the presence of a low anion gap in 50 patients with asymptomatic plasma cell dyscrasias. No correlation was found between the size of the anion gap and the height of the paraprotein "spike" or the size of the anion gap and an index of the net cationic charge of the monoclonal immunoglobulins.
多发性骨髓瘤患者中低阴离子间隙的存在最近已受到关注。这与氯离子和碳酸氢根离子的潴留有关，以抵消单克隆免疫球蛋白的阳离子电荷。我们现在报告50例无症状浆细胞发育异常患者存在低阴离子间隙。未发现阴离子间隙大小与副蛋白“峰”的高度之间存在相关性，也未发现阴离子间隙大小与单克隆免疫球蛋白净阳离子电荷指数之间存在相关性。
