Drake R E, Adcock D K, Scott R L, Gabel J C
Circ Res. 1982 Jun;50(6):865-9. doi: 10.1161/01.res.50.6.865.
The pulmonary lymph flow rate (QL) should be a function of the lymph vessels' resistance and the pressure gradient along the vessels. We attempted to study how these factors affect lymph flow. We assumed that the lymph system could be represented by a single pressure generated within the lung (PL) and a single resistance (RL). Thus, QL should be a function of the lymph vessel outflow pressure (Po): QL = (PL - Po)/RL. We cannulated tracheobronchial lymph vessels in eight anesthetized dogs and varied Po by raising the outflow end of the cannula. QL decreased linearly when we increased Po. We estimated RL as - delta Po/ delta QL and PL as the extrapolated Po at which QL = 0. At baseline PL = 7.7 +/- 2.7 (SD) cm H2O and RL = 0.36 +/- 0.25 cm H2O. min/microliters. After we increased capillary pressure to produce edema, PL and RL averaged 22.8 +/- 8.8 and 0.14 +/- 0.12, respectively. After we reduced the capillary pressure to baseline in the edematous lungs, PL and RL averaged 11.6 +/- 2.8 and 0.08 +/- 0.09, respectively. All changes in PL and RL were significant (P less than 0.05). These results show that (1) lymph flow rate depends upon lymph vessel outflow pressure, and (2) the QL vs. Po relationship is changed by edema. PL may be equal to the pressure causing lymph to flow and RL may equal the lymph vessel resistance.
肺淋巴液流速（QL）应是淋巴管阻力以及沿淋巴管压力梯度的函数。我们试图研究这些因素如何影响淋巴液流动。我们假定淋巴系统可用肺内产生的单一压力（PL）和单一阻力（RL）来表示。因此，QL应是淋巴管流出压力（Po）的函数：QL = (PL - Po)/RL。我们在八只麻醉犬身上插管至气管支气管淋巴管，并通过抬高插管的流出端来改变Po。当我们增加Po时，QL呈线性下降。我们将RL估计为 -ΔPo/ΔQL，将PL估计为QL = 0时外推得到的Po。在基线时，PL = 7.7 ± 2.7（标准差）cm H₂O，RL = 0.36 ± 0.25 cm H₂O·min/微升。在增加毛细血管压力以产生水肿后，PL和RL的平均值分别为22.8 ± 8.8和0.14 ± 0.12。在将水肿肺的毛细血管压力降至基线后，PL和RL的平均值分别为11.6 ± 2.8和0.08 ± 0.09。PL和RL的所有变化均具有显著性（P < 0.05）。这些结果表明：（1）淋巴液流速取决于淋巴管流出压力；（2）水肿会改变QL与Po的关系。PL可能等于促使淋巴液流动的压力，而RL可能等于淋巴管阻力。
