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功能失调的二尖瓣和主动脉瓣再次置换的院内风险。

The in-hospital risk of rereplacement of dysfunctional mitral and aortic valves.

作者信息

Cohn L H, Koster J K, VandeVanter S, Collins J J

出版信息

Circulation. 1982 Aug;66(2 Pt 2):I153-6.

PMID:7083536
Abstract

From January 1, 1972, to January 1, 1981, 1282 consecutive valve replacements were performed at the Peter Bent Brigham Hospital. Fifty-eight of these (4.5%) were rereplacements: 14 for prosthetic valve subacute bacterial endocarditis (SBE), 29 for primary valve dysfunction (PVD) and 15 for perivalvular leak (PVL). Aortic rereplacement was done in 27 patients (eight for SBE, 10 for PVD and nine for PVL) and mitral rereplacement in 31 patients (six for SBE, 19 for PVD and six for PVL). Twenty-six patients were in New York Heart Association functional class III and 32 were in class IV. Ten class IV patients underwent emergency valve replacement (three for SBE, two for PVD and five for PVL). The overall in-hospital mortality rate for valve rereplacement was 14% (eight of 58 patients). For mitral valve rereplacement it was 13% (four of 31), compared with 6.4% (19 of 295) for initial mitral valve replacement. For aortic valve rereplacement, the mortality rate was 15% (four of 27), compared with 5.2% (23 of 440) for initial aortic valve replacement. The cause of death was low cardiac output in six patients, hemorrhage in one patient and sepsis in one patient. All of the patients who died were in functional class IV (p = 0.018). The in-hospital risk for rereplacement of a dysfunctional aortic or mitral valve is no different from that for primary valve replacement unless the patient deteriorates to class IV and requires an emergent operation.

摘要

1972年1月1日至1981年1月1日期间,彼得·本特·布里格姆医院连续进行了1282例瓣膜置换手术。其中58例(4.5%)为再次置换手术:14例因人工瓣膜亚急性细菌性心内膜炎(SBE),29例因原发性瓣膜功能障碍(PVD),15例因瓣周漏(PVL)。27例患者进行了主动脉瓣再次置换(8例因SBE,10例因PVD,9例因PVL),31例患者进行了二尖瓣再次置换(6例因SBE,19例因PVD,6例因PVL)。26例患者为纽约心脏协会心功能Ⅲ级,32例为Ⅳ级。10例Ⅳ级患者接受了急诊瓣膜置换手术(3例因SBE,2例因PVD,5例因PVL)。瓣膜再次置换的总体院内死亡率为14%(58例患者中的8例)。二尖瓣再次置换的死亡率为13%(31例中的4例),而初次二尖瓣置换的死亡率为6.4%(295例中的19例)。主动脉瓣再次置换的死亡率为15%(27例中的4例),而初次主动脉瓣置换的死亡率为5.2%(440例中的23例)。死亡原因6例为心输出量低,1例为出血,1例为败血症。所有死亡患者均为心功能Ⅳ级(p = 0.018)。功能障碍的主动脉瓣或二尖瓣再次置换的院内风险与初次瓣膜置换无异,除非患者病情恶化至Ⅳ级并需要急诊手术。

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