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D-青霉胺与消胆胺的体外结合研究。

Studies on the in vitro binding of D-penicillamine to cholestyramine.

作者信息

Allgayer H, Kruis W, Paumgartner G

出版信息

Experientia. 1982 Apr 15;38(4):482-4. doi: 10.1007/BF01952651.

DOI:10.1007/BF01952651
PMID:7084416
Abstract

Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4-8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/l) inhibited this small adsorption by 87%.

摘要

青霉胺对消胆胺的吸附作用取决于树脂的量、pH值以及其他化合物如胆盐的存在。在通常的药物与树脂比例(每单剂量150毫克青霉胺和4 - 8克消胆胺)下,吸附到消胆胺上的青霉胺百分比约为给药剂量的10%;胆盐(10毫摩尔/升)可使这种少量吸附减少87%。

相似文献

1
Studies on the in vitro binding of D-penicillamine to cholestyramine.D-青霉胺与消胆胺的体外结合研究。
Experientia. 1982 Apr 15;38(4):482-4. doi: 10.1007/BF01952651.
2
Binding of bile acids to cholestyramine at gastric pH conditions.在胃pH条件下胆汁酸与考来烯胺的结合。
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Adsorption of bile acids by sucralfate, antacids, and cholestyramine in vitro.硫糖铝、抗酸剂和考来烯胺在体外对胆汁酸的吸附作用。
Clin Ther. 1987;9(6):615-21.
4
Comparison of antacids on the binding of bile salts.
Arch Surg. 1984 Sep;119(9):1018-20. doi: 10.1001/archsurg.1984.01390210022006.
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The ability of antacids and cholestyramine to bind bile acids: effect of pH.抗酸剂和消胆胺结合胆汁酸的能力:pH值的影响
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In vitro adsorption of bile salts and aspirin to sucralfate.硫糖铝对胆盐和阿司匹林的体外吸附作用
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Effect of competing anions on binding of bile salts by cholestyramine.竞争性阴离子对消胆胺结合胆盐的影响。
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Quantification of the binding tendencies of cholestyramine. 3. Rates of adsorption of conjugated bile salt anions onto cholestyramine as a function of added inorganic electrolyte concentration, temperature, and agitation intensity.考来烯胺结合倾向的定量分析。3. 结合胆汁盐阴离子在考来烯胺上的吸附速率与添加的无机电解质浓度、温度和搅拌强度的关系。
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引用本文的文献

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Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer.在人结肠黏膜DNA模型中胆汁酸和水杨酸盐对碱基羟基化的调节作用:对结肠癌的潜在影响
Dig Dis Sci. 1999 Apr;44(4):761-7. doi: 10.1023/a:1026670027150.

本文引用的文献

1
CHOLESTYRAMINE RESIN THERAPY FOR HYPERCHOLESTEREMIA: CLINICAL AND METABOLIC STUDIES.考来烯胺树脂治疗高胆固醇血症:临床与代谢研究
JAMA. 1965 Apr 26;192:289-93. doi: 10.1001/jama.1965.03080170017004.
2
Treatment of pruritus of obstructive jaundice with cholestyramine.用考来烯胺治疗梗阻性黄疸瘙痒症。
Br Med J. 1963 Jan 26;1(5325):216-9. doi: 10.1136/bmj.1.5325.216.
3
Colorimetric estimation of penicillamine.
J Biol Chem. 1959 Mar;234(3):618-9.
4
The interaction between cholestyramine and drugs.消胆胺与药物之间的相互作用。
Proc Soc Exp Biol Med. 1965 Oct;120(1):60-5. doi: 10.3181/00379727-120-30443.
5
Quantification of the binding tendencies of cholestyramine. I. Effect of structure and added electrolytes on the binding of unconjugated and conjugated bile-salt anions.消胆胺结合倾向的定量研究。I. 结构和添加电解质对未结合及结合型胆盐阴离子结合的影响。
J Pharm Sci. 1969 Feb;58(2):179-83. doi: 10.1002/jps.2600580206.
6
A disorder of copper metabolism treated with penicillamine in a patient with primary biliary cirrhosis and renal tubular acidosis.一名原发性胆汁性肝硬化和肾小管酸中毒患者,其铜代谢紊乱采用青霉胺治疗。
Am J Med. 1967 Oct;43(4):620-35. doi: 10.1016/0002-9343(67)90185-4.
7
Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.考来烯胺对洋地黄毒苷肝肠循环的阻断作用。I. 对致死性洋地黄毒苷中毒的保护作用。
J Clin Invest. 1971 Dec;50(12):2626-37. doi: 10.1172/JCI106763.
8
Effect of cholestyramine on bile acid metabolism in normal man.消胆胺对正常人胆汁酸代谢的影响。
J Clin Invest. 1972 Nov;51(11):2781-9. doi: 10.1172/JCI107100.
9
Drug-cholestyramine interactions. I. Physicochemical factors affecting in vitro binding of sodium fusidate to cholestyramine.药物-消胆胺相互作用。I. 影响夫西地酸钠与消胆胺体外结合的物理化学因素。
J Pharm Sci. 1972 May;61(5):730-5. doi: 10.1002/jps.2600610512.
10
Inhibitory effect of cholestyramine on the absorption of flufenamie and mefenamic acids in rats.消胆胺对大鼠氟芬那酸和甲芬那酸吸收的抑制作用。
Proc Soc Exp Biol Med. 1974 Jan;145(1):93-8. doi: 10.3181/00379727-145-37755.