2,3,7,8-四溴二苯并二恶英在大鼠体内的代谢

The metabolism of 2,3,7,8-tetrabromodibenzodioxin in the rat.

De Jongh J, Buser H R, Poiger H

Research Institute of Toxicology, University of Utrecht, The Netherlands.

Xenobiotica. 1993 Jan;23(1):19-26. doi: 10.3109/00498259309059358.

Abstract

2,3,7,8-Tetrabromodibenzodioxin was administered to bile-duct-cannulated rats in a single oral dose. 2. The compound was metabolized in the liver and metabolites were secreted into the bile. 3. Several phenolic metabolites were identified as their methyl ether derivatives by gas chromatography-mass spectrometry after clean-up and methylation of bile samples. 4. The main metabolites were formed by aromatic hydroxylation and via displacement of Br-substituents (hydrolytic debromination). 5. Trace amounts of unmetabolized TBDD were also present in the bile.

摘要

给胆管插管的大鼠一次性口服2,3,7,8-四溴二苯并二恶英。2. 该化合物在肝脏中代谢，代谢产物分泌到胆汁中。3. 胆汁样品经过净化和甲基化处理后，通过气相色谱-质谱法将几种酚类代谢产物鉴定为它们的甲基醚衍生物。4. 主要代谢产物是通过芳香族羟基化和溴取代基的置换（水解脱溴）形成的。5. 胆汁中也存在痕量未代谢的四溴二苯并二恶英。