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3H-2-亚氨基-7-甲基-4-氧代吡啶并[3,2-e]-1,3-噻嗪-6-羧酸乙酯新衍生物及异构化合物的合成与性质研究

Investigations on the synthesis and properties of new derivatives of ethyl 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-6-carboxylate and isomeric compounds.

作者信息

Sladowska H, Zawisza T

出版信息

Farmaco Sci. 1982 Apr;37(4):247-58. doi: 10.1002/chin.198239266.

DOI:10.1002/chin.198239266
PMID:7084447
Abstract

Condensation of diethyl 2-chloro-6-methylpyridine-3,5-dicarboxylate (IV) with thiourea and alkyl or alkenyl N-mono- and N,N'-disubstituted thioureas gives mainly the corresponding derivatives of ethyl 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-6-carboxylate (VI-XII). As by-products isomeric derivatives of ethyl 7-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d) pyrimidine-6-carboxylate (XIII-XVIII) are formed.

摘要

2-氯-6-甲基吡啶-3,5-二羧酸二乙酯（IV）与硫脲以及烷基或烯基N-单取代和N,N'-二取代硫脲缩合，主要生成3H-2-亚氨基-7-甲基-4-氧代吡啶并[3,2-e]-1,3-噻嗪-6-羧酸乙酯（VI - XII）的相应衍生物。作为副产物，生成了7-甲基-4-氧代-2-硫代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-羧酸乙酯（XIII - XVIII）的异构体衍生物。

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