Zawisza T, Siwińska B, Sladowska H, Jakóbiec T
Farmaco Sci. 1982 Apr;37(4):266-74.
Condensation of dimethyl 2-chloro-6-methylpyridine-3,4-dicarboxylate with thiourea and its N-substituted derivatives is described. It has been found that depending on the kind of substituents in the starting thiourea derivatives, pyrido [3,2-e]-1,3-thiazine or pyrido [2,3-d] pyrimidine derivatives were formed.
描述了2-氯-6-甲基吡啶-3,4-二甲酸二甲酯与硫脲及其N-取代衍生物的缩合反应。已发现,根据起始硫脲衍生物中取代基的种类,会形成吡啶并[3,2-e]-1,3-噻嗪或吡啶并[2,3-d]嘧啶衍生物。