Sladowska H, Bartoszko-Malik A, Zawisza T
Department of Chemistry of Drugs, School of Medicine, Wroclaw, Tamka, Poland.
Farmaco. 1990 Jan;45(1):101-10. doi: 10.1002/chin.199037219.
Condensation of diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate with phenyl or cyclohexyl isocyanates gave the corresponding derivatives of ethyl 7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine- 5-carboxylate[(V), (VI)]. Alkylation of (V) and (VI) afforded the corresponding N-1 substituted derivatives (XI-XIX).
2-氨基-6-甲基吡啶-3,4-二羧酸二乙酯与苯基或环己基异氰酸酯缩合得到7-甲基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-5-羧酸乙酯的相应衍生物[(V), (VI)]。(V)和(VI)的烷基化反应得到相应的N-1取代衍生物(XI - XIX)。
