Kassil' V G, Butkevich I P, Mikhaĭlenko V A
Fiziol Zh SSSR Im I M Sechenova. 1982 Apr;68(4):498-502.
The effects of self-stimulation (SS) of the brain reward sites on the gastric secretion were studied in 8 adult dogs with gastric fistula. The concentric (bipolar) electrodes were implanted in different sites of the brain reward system (hypothalamus, mamillary corpus, capsula interna, commissura grisea media, n. interstitialis striae terminalis, n. ventralis thalami, pes pedunculi cerebri) and then the instrumental reaction of the intracranial self-stimulation (ICSS) was induced. On recovery period normal acidity of the gastric juice was observed in 5 hungary dogs whereas in 3 hungry dogs the gastric acidity was significantly increased. In 3-5 min after the beginning of SS a lot of thick foamy slime and turbid juice was secreted. In dogs with initially normal pH of the gastric contents ICSS did not change it, whereas in dogs with increased pH ICSS made the gastric acidity normal pH of the gastric contents ICSS did not change it, whereas in dogs with increased pH ICSS made the gastric acidity normal. Bilateral supradiaphragmal vagotomy reduced the acidity in the animals of the last group, but only ICS made their pH quite normal. Therefore, positive emotional excitement associated with the stimulation of different areas of the brain reward system, makes gastric acidity normal and this reaction is not connected with the efferent systems of vagus nerves.
