Kassil' V G, Butkevich I P, Mikhailenko V A
Neurosci Behav Physiol. 1984 Sep-Oct;14(5):395-9. doi: 10.1007/BF01184609.
The influence of the self-stimulation (SS) positive-reinforcement zones of the brain on the secretion of gastric juice was investigated using eight adult dogs with gastric fistulas. An intracerebral-S3 instrumental response was developed after implanting concentric (bipolar) electrodes into various zones of the reward system (hypothalamus, mammillary bodies, ventral thalamic nucleus, commissura grisea media, internal capsule, nucleus of the stria terminalis, and the crus cerebri). A normal acidity of the stomach contents was found in five dogs after surgery during the interdigestive period and a sharply elevated acidity in three dogs. A large quantity of thick foamy mucus and a turbid juice was secreted 3-5 min after the onset of SS. Self-stimulation did not alter the pH of the stomach contents in dogs with an initially normal pH, while it normalized this parameter in dogs with an initially elevated acidity. Bilateral supradiaphragmatic vagotomy in the animals of the latter group shifted the pH in the alkaline direction; however, the pH was completely normalized only as a result of intracerebral SS. Thus, positive emotional excitation associated with the stimulation of various reward zones normalized the acidity of the stomach contents; moreover, this response was not associated with the efferent systems of the vagus nerves.
使用八只患有胃瘘的成年犬，研究了大脑自我刺激（SS）阳性强化区对胃液分泌的影响。在将同心（双极）电极植入奖赏系统的各个区域（下丘脑、乳头体、腹侧丘脑核、灰质连合、内囊、终纹核和大脑脚）后，建立了脑内-S3工具性反应。术后，五只犬在消化间期胃内容物酸度正常，三只犬酸度急剧升高。自我刺激开始后3-5分钟，分泌出大量浓稠泡沫状黏液和浑浊的胃液。自我刺激并未改变初始pH值正常的犬胃内容物的pH值，而使初始酸度升高的犬的这一参数恢复正常。后一组动物进行双侧膈上迷走神经切断术后，pH值向碱性方向转变；然而，仅通过脑内自我刺激，pH值才完全恢复正常。因此，与刺激各种奖赏区相关的积极情绪兴奋使胃内容物酸度恢复正常；此外，这种反应与迷走神经的传出系统无关。
