Seitz H, Czygan P, Kommerell B
Digestion. 1982;23(1):65-7. doi: 10.1159/000198711.
The effect of chronic ethanol administration on the incorporation of 3H-thymidine into DNA of isolated intestinal cells in the rat was investigated. Chronic ethanol consumption increased significantly DNA synthesis in intestinal mucosal cells. Whether this enhancement of DNA synthesis as a measure for cellular regeneration is due to the local effect of ethanol via tissue injury, to a direct stimulatory effect of ethanol on enzyme activities involved in DNA metabolism or to a change in the intestinal cell population with a shift to immature crypt cells by ethanol is not known.
研究了长期给予乙醇对大鼠离体肠细胞DNA中3H-胸腺嘧啶核苷掺入的影响。长期摄入乙醇可显著增加肠黏膜细胞中的DNA合成。这种作为细胞再生指标的DNA合成增强，究竟是由于乙醇通过组织损伤产生的局部效应、乙醇对参与DNA代谢的酶活性的直接刺激作用，还是由于乙醇导致肠细胞群体发生变化，向未成熟的隐窝细胞转变，目前尚不清楚。
