Vanderhoof J A, Tuma D J, Antonson D L, Sorrell M F
Digestion. 1982;23(1):9-15. doi: 10.1159/000198705.
Administration of antibiotics has been reported to prevent or minimize liver dysfunction in experimental animals having been subjected to jejunoileal bypass, suggesting that jejunoileal bypass-induced liver dysfunction results from production of toxic substances by bacteria in the defunctionalized bowel. However, improved absorption will also prevent bypass-induced liver injury. We studied the effects of tetracycline on the development of bypass-induced liver dysfunction and compared it to the mucosal adaptation of the intact bowel after bypass. After 6 weeks, rats subjected to bypass but not given antibiotics had decreased levels of serum triglycerides, hepatic cytochrome P-450, and hepatic pentobarbital hydroxylase. Evaluation of intestinal mucosal hyperplasia after bypass indicated that animals given antibiotics after bypass developed greater increases in mucosal DNA content, mucosal protein, and mucosal weight than bypassed animals not receiving antibiotics. We speculate that the beneficial effects of antibiotic administration on liver function after bypass may be a result of improved absorption.
据报道，在接受空肠回肠旁路术的实验动物中，使用抗生素可预防或减轻肝功能障碍，这表明空肠回肠旁路术引起的肝功能障碍是由失功能肠段中的细菌产生有毒物质所致。然而，吸收改善也可预防旁路引起的肝损伤。我们研究了四环素对旁路诱导的肝功能障碍发展的影响，并将其与旁路后完整肠段的黏膜适应性进行了比较。6周后，接受旁路手术但未使用抗生素的大鼠血清甘油三酯、肝细胞色素P-450和肝戊巴比妥羟化酶水平降低。对旁路后肠黏膜增生的评估表明，旁路后使用抗生素的动物黏膜DNA含量、黏膜蛋白和黏膜重量的增加幅度大于未接受抗生素的旁路动物。我们推测，旁路术后使用抗生素对肝功能的有益作用可能是吸收改善的结果。
