Waye J D, Braufeld S F
Gastrointest Endosc. 1982 May;28(2):86-7. doi: 10.1016/s0016-5107(82)73006-8.
Forty-five patients having ambulatory colonoscopic examinations were randomly assigned to receive premedication with meperidine or with nalbuphine. Both treatment groups received equivalent amounts of intravenous diazepam as an additional sedative. Approximately half of the patients tolerated the procedure well in either treatment arm, but a significantly greater number of patients receiving nalbuphine tolerated the procedure poorly, even with large doses of medication. Nalbuphine does not appear to be as effective as meperidine for relieving the discomfort induced by colonoscopy.
45名接受门诊结肠镜检查的患者被随机分配接受哌替啶或纳布啡进行术前用药。两个治疗组均接受等量的静脉注射地西泮作为额外的镇静剂。在两个治疗组中，大约一半的患者对该操作耐受良好，但接受纳布啡治疗的患者中，即使使用大剂量药物，仍有明显更多的患者对该操作耐受较差。对于缓解结肠镜检查引起的不适，纳布啡似乎不如哌替啶有效。
