Russell D, Fritz V, Mieny C J, Mendelsohn D, Joffe B I, Seftel H C
S Afr Med J. 1979 Feb 17;55(7):237-40.
Ten patients with heterozygous familial hypercholesterolaemia (Fredrickson type II) were treated by the operation of partial ileal bypass. Postoperatively, serum cholesterol levels fell by an average of 34% (P less than 0.005), and the decrease was satisfactorily sustained over a period of 12-30 months. Angina and xanthomas also improved in some patients. Postoperatively all patients experienced considerable diarrhoea, which lessened with time. Other complications of surgery included abdominal distension and cramps, colonic dilatation, sepsis and intestinal obstruction. It is concluded that partial ileal bypass significantly lowers serum cholesterol levels, but that in view of the complications the operation should be offered only to carefully selected patients who are intolerant of or unresponsive to conservative measures.
10例杂合子家族性高胆固醇血症（弗雷德里克森II型）患者接受了部分回肠旁路手术治疗。术后，血清胆固醇水平平均下降了34%（P<0.005），且在12至30个月的时间内下降情况保持良好。部分患者的心绞痛和黄色瘤也有所改善。术后所有患者均出现明显腹泻，随着时间推移腹泻减轻。手术的其他并发症包括腹胀、痉挛、结肠扩张、败血症和肠梗阻。结论是，部分回肠旁路手术可显著降低血清胆固醇水平，但鉴于其并发症，该手术应仅提供给对保守治疗不耐受或无反应的经过精心挑选的患者。
